RESUMO
Trypanosoma brucei is the etiological agent of African trypanosomiasis responsible for human and animal infections. T. brucei is transmitted by infected tsetse flies. There is no vaccine for the disease and drugs available for treatment are inefficient and high toxicity. In this context, it is a priority to find antigenic targets suitable for the development of new diagnostic tools, drugs and vaccines. In this work, we report that mice infected with T. b. brucei produce antibodies against trans-sialidase recombinant protein (TS). In addition, we also demonstrate that bloodstream T. b. brucei express messenger RNA related to the TS gene. Collectively, our data strongly suggest that bloodstream forms of T. b. brucei also express the TS gene, that to date was described only in the procyclic forms of the T. b. brucei. In conclusion, these results highlight the importance of TS protein as a possible antigen target during infection caused by T. b. brucei.
Assuntos
Regulação Enzimológica da Expressão Gênica , Neuraminidase/sangue , Proteínas de Protozoários/sangue , Trypanosoma brucei brucei/enzimologia , Tripanossomíase Africana/sangue , Animais , Biomarcadores/sangue , Humanos , Camundongos , Neuraminidase/genética , Proteínas de Protozoários/genética , Trypanosoma brucei brucei/genética , Tripanossomíase Africana/genéticaRESUMO
El presente trabajo presenta un estudio sistemático con el objetivo de caracterizar y analizar el perfil de la población asistida por el equipo de salud mental comunitario del Departamento de Salud Mental de Guarda, en términos de características sociodemográficas y clínicas, con vistas a mejorar la práctica asistencial en el futuro. Así, se realizó un estudio descriptivo retrospectivo de todos los procesos clínicos de pacientes con trastorno mental incluidos en el servicio comunitario. Se analizaron datos sociodemográficos (edad, sexo y estado civil), características clínicas, diagnóstico, tratamiento y año de hospitalización. Un total de 287 casos fueron identificados e investigados. El perfil común del paciente inscrito en el Servicio de Salud Mental de la Comunidad fue el sexo masculino (72,5%), con una edad promedio de 52 años, en su mayoría solteros (74,5%) y con diagnóstico de esquizofrenia y psicosis relacionadas (54,7%). La totalidad de los pacientes fue tratada con antipsicóticos de acción prolongada y el fármaco más utilizado fue el decanoato de haloperidol (46%). Un detalle particular fue que el 25% de los pacientes nunca fueron ingresados en el servicio psiquiátrico. Este estudio permitió determinar el perfil de los pacientes asistidos, pero también muestra que todos los pacientes inscritos en el Servicio de Salud Mental se benefician de la consulta periódica del servicio comunitario, que proporciona apoyo clínico, social y familiar en el propio domicilio, y promueve la adherencia terapéutica con uso de antipsicóticos de acción prolongada
The present work presents a systematic study aiming to characterize and analyze the profile of the population that is assisted by the community mental health team of Guarda Metal Health Department, in terms of sociodemographic and clinic features, in order to improve the assistance practice in the future. For that matter, a retrospective study of all patient clinical records with mental disorder included in the home care program was conducted. Sociodemographic data (age, sex and marital status), clinical features, diagnosis, treatment and year of hospitalization were analyzed. A total of 287 cases were identified and investigated. The common profile of patient enrolled into the Community Mental Health Service was male (72,5 %), mean age of 52 years, generally single (74,5%), and diagnosed with schizophrenia and related psychoses (54,7%). The totality of the patients was treated with antipsychotic longacting injections, therefore, the most frequent treatment was haloperidol decanoate (46%). One particular detail was that 25% of the patients were never admitted to the psychiatric service. This study allowed to determine the profile of patients assisted but also show that all the patient enrolled into the Community Mental Health Service benefits from the periodic consultation of the home care program, which provides clinical, social and family support, as well as promote therapeutic adherence with long-acting antipsychotic injections
